Prioritize safety and medical supervision when choosing a weight-loss pill. Today's evidence supports prescription options (GLP-1s, orlistat, combination drugs) used alongside diet and exercise; avoid unproven supplements.
Prescription weight-loss drugs - from orlistat to newer GLP-1/GIP therapies - can help people with clinically significant obesity, but they require medical oversight. Understand who qualifies, likely side effects, and risks of herbal alternatives.
Modern weight-loss drugs either curb appetite or block fat absorption. They can help when combined with diet and exercise, but they carry side effects and are not quick fixes.