Blackheads are open comedones caused by sebum and retained skin cells in the pilosebaceous unit, with Cutibacterium acnes sometimes contributing. Effective treatment focuses on topical retinoids to normalize follicular turnover, keratolytics (salicylic acid), and benzoyl peroxide when inflammation is present. Topical or oral antibiotics are reserved for inflammatory acne and should not be used alone. In-office extraction and dermatologic procedures can help persistent cases.
What are blackheads?
Blackheads (open comedones) are a common form of acne. They form when the pilosebaceous unit - the hair follicle plus its sebaceous (oil) gland - becomes plugged with excess sebum and shed skin cells. Because the follicle opening is exposed to air, the trapped material darkens by oxidation and appears as a small dark spot, not because of dirt.
What causes them?
Several factors contribute: increased sebum production, abnormal shedding of follicular cells (hyperkeratinization), and colonization by Cutibacterium acnes. These changes can create a noninflammatory plug (a comedo). If bacteria and inflammation increase, the lesion can become a red bump or pustule.
First-line treatments for blackheads
Topical retinoids (adapalene, tretinoin, tazarotene) are the most effective first-line treatment for comedonal acne. They normalize follicular cell turnover and help clear and prevent plugs. Lower-strength adapalene (0.1%) is available over the counter in many countries.
Keratolytic agents such as salicylic acid and topical exfoliants can loosen and remove the plug. Over-the-counter products that contain 0.5-2% salicylic acid or alpha-hydroxy acids may help with mild cases.
Benzoyl peroxide reduces bacteria and can be useful when inflammatory lesions are present. It is often combined with other agents to limit bacterial resistance.
What about antibiotics?
Topical antibiotics (for example, clindamycin) were used historically, but they are not the primary treatment for noninflammatory blackheads. When antibiotics are used, clinicians recommend combining them with benzoyl peroxide or a retinoid to reduce the risk of antibiotic resistance. Oral antibiotics are reserved for more inflammatory or widespread acne and are not ideal for isolated blackheads.
Procedures and when to see a clinician
Manual comedo extraction by a trained clinician can give immediate improvement for stubborn plugs. Chemical peels, microdermabrasion, and in-office retinoid procedures are additional options for persistent cases.
If blackheads are widespread, painful, or not responding to OTC regimens after several months, see a dermatologist. They can prescribe stronger retinoids, combination topicals, or evaluate for underlying causes.
Practical tips
- Use a gentle, noncomedogenic cleanser and avoid harsh scrubs that irritate skin.
- Introduce topical retinoids slowly to reduce irritation.
- Be consistent: comedonal acne often needs weeks to months of treatment to improve.
- Avoid squeezing lesions at home; improper extraction can cause scarring.
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