Lifestyle changes - Mediterranean/DASH diet, weight control, and exercise - are the most effective ways to lower cholesterol. Several supplements (plant sterols/stanols, soluble fiber, omega-3s, green tea, red yeast rice) have modest effects; niacin is no longer routinely recommended. Supplements can interact with drugs and vary in quality, so coordinate care with your clinician and monitor lipids and safety labs.
Why consider non-drug approaches?
Improved medicine means more people live to older ages, and cardiovascular disease remains a leading concern. Prescription statins lower LDL cholesterol and reduce heart attacks and strokes in people at risk, but they can cause muscle pain, liver enzyme changes, and other side effects in some patients. That makes sensible lifestyle and supplement strategies an important part of care - either alongside medications or, for lower-risk people, as first-line steps.
Diet and lifestyle first
The strongest evidence for lowering cholesterol comes from diet and lifestyle. Adopt a Mediterranean or DASH-style eating pattern: emphasize vegetables, fruits, whole grains, legumes, nuts, olive oil, and fatty fish. Reduce saturated and trans fats, limit processed foods, and aim for a healthy weight. Regular aerobic exercise, smoking cessation, and modest alcohol intake also help.
Supplements and plant-based options with evidence
- Plant sterols and stanols: Found in fortified foods and supplements, these compounds reduce intestinal cholesterol absorption and can lower LDL cholesterol modestly when used consistently.
- Soluble fiber (psyllium, oats, legumes): Adds bulk in the gut and reduces LDL slightly; a practical, low-risk option.
- Omega-3 fatty acids (fish oil): Over-the-counter fish oil lowers triglycerides. A prescription formulation of purified EPA has shown cardiovascular benefit in selected high-risk patients, while results for general use are mixed.
- Green tea: Catechins in green tea have modest lipid and antioxidant effects. Benefits are small and best seen as part of an overall healthy diet.
- Red yeast rice: Contains monacolin K, a natural form of lovastatin, and can lower LDL. Because it acts like a statin, it can cause similar side effects and interacts with drugs; product quality varies.
- Niacin: Once used to raise HDL cholesterol, large trials found no cardiovascular benefit and measurable risks (flushing, glucose changes, liver concerns). It is no longer routinely recommended to improve outcomes.
How supplements fit with medical care
Supplements can complement diet and exercise, but they are not risk-free. Some interact with prescription medications, and potency varies between products. If you have high cholesterol or are considering stopping a prescription drug, discuss options with your clinician. Monitoring (lipid panels, liver tests, symptom review) helps ensure safety and effectiveness.
Practical approach
Start with proven lifestyle measures: diet, weight management, and exercise. Use evidence-based supplements (plant sterols, soluble fiber, appropriate omega-3s) as adjuncts when needed. Consider medications when risk is high or lifestyle and supplements do not achieve targets. Shared decision-making with a healthcare professional helps balance benefits, risks, and personal priorities.